CN103006274A - Method and system for ultrasonic detection of cornea viscoelasticity - Google Patents
Method and system for ultrasonic detection of cornea viscoelasticity Download PDFInfo
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Abstract
The invention discloses a method and system for ultrasonic detection of cornea viscoelasticity. The method comprises the following steps of firstly, focusing sound waves with certain power onto a cornea to generate a sound radiant force on the cornea; under the action of the sound radiant force, the cornea generating slight vibration, and the vibration propagating outwards in the cornea in a Lamb wave way; then, transmitting a detection pulse to an eyeball, the pulse reflecting in the tissues of the eyeball to form echo, and receiving the echo; and finally, extracting the vibration information of the cornea from the echo, and according to a certain mathematical model, obtaining an elastic module and a viscosity coefficient of the cornea. The elastic module and the viscosity coefficient can be simultaneously and quantitatively measured, and mechanical properties of the cornea are fully described. Meanwhile, the system has the advantages that the structure is simple, easy implementation is realized, the cost is low, and the like. The system can be used as independent equipment, and also can be used as an additional function module to be loaded onto the existing color ultrasonic system for use, so the market population prospect is better.
Description
Technical field
The present invention relates to the ultrasonic detecting technology field, relate in particular to the viscoelastic method and system of a kind of ultrasound detection cornea.
Background technology
Cornea is the circular transparent configuration of eyeball front portion, and it not only keeps eyeball shape protection eye inner tissue jointly with sclera, and is the important component part of eye refraction system, and its shape and focal length affect 70% of full refraction of eye ability.As a kind of biological tissue, cornea shows the biomechanics characteristics such as nonlinear strain-stress relation, anisotropy, viscoelasticity.These mechanical characteristics not only present obvious individual variation, and can change because of cornea refractive surgery, some pathological changes or wound; On the other hand, mechanical characteristic unusually will not only increase the risk of cornea refractive surgery, also can cause the deviation of measure of intraocular pressure and then affect glaucomatous early diagnosis.
At present, the Fink of Paris, FRA university professor seminar proposes a kind of corneal elasticity quantitative imaging based on THE ADIABATIC SHEAR IN ripple imaging system, adopt the low-frequency vibration of ultrasonic radiation force excitation 500 to 3000Hz, rely on the Lamb wave that produces in high-speed ultrasonic imaging technique (frame frequency can the reach tens thousand of frames) corneal to carry out imaging, estimate the Young's modulus of cornea according to the phase velocity of Lamb wave.
This research has been showed based on the probability of ultrasonic method acquisition at body corneal elasticity figure for us, but also there is certain limitation: the first, the method must could realize system complex by the THE ADIABATIC SHEAR IN ripple imaging device that this team has an autonomous property right, involve great expense, be not easy to promote; In addition, the method has only been estimated Young's modulus, does not consider the viscosity of cornea, can not accurately reflect the mechanical characteristic of tissue.
In view of this, prior art haves much room for improvement and improves.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to provide a kind of ultrasound detection cornea viscoelastic method and system.Be intended to solve ultrasonic method in the prior art obtain the body corneal elasticity strive for survival complicated, the problem that can't comprehensively reflect mechanical characteristic of equipment.
Technical scheme of the present invention is as follows:
The viscoelastic method of a kind of ultrasound detection cornea wherein, said method comprising the steps of:
The sound wave focusing that S1, order have certain power is on cornea, and corneal produces an acoustic radiation force; Under the effect of described acoustic radiation force, cornea produces microvibration, and described vibration form with Lamb wave in cornea is outwards propagated;
S2, detect pulse to eyeball emission, described pulse forms echo in the eyeball tissue internal reflection, and receives described echo;
The information of S3, the vibration of extraction cornea from echo, and according to certain mathematical model, obtain elastic modelling quantity and the viscosity of cornea.
Preferably, the viscoelastic method of described ultrasound detection cornea, wherein, among the described step S3, the information of the vibration of cornea comprises: the waveform of vibration, and the phase velocity of Lamb wave is with the change information of frequency.
Preferably, the viscoelastic method of described ultrasound detection cornea wherein, also comprises before the described step S1: oscillation starting points F and at least two test points with fine pitch of definition cornea; The test point emission detects pulse, with the home position of record cornea.
The viscoelastic system of a kind of ultrasound detection cornea wherein, comprising: main control computer, radiating circuit, receiving circuit, ultrasonic probe; Described main control computer connects radiating circuit and receiving circuit respectively by the transmitting/receiving gauge tap, each array element emission or reception ultrasonic pulse on the control ultrasonic probe;
Probe minute a plurality of array elements, wherein a part of array element is used for the emission acoustic radiation force, the vibration of excitation tissue, other has some array elements to be used for the emission ultrasonic pulse, and receives echo-signal, thereby detects the vibration information of tissue.
Beneficial effect:
The application's the viscoelastic method and system of ultrasound detection cornea, but simultaneous quantitative is measured elastic modelling quantity and viscosity, portrays the mechanical characteristic of cornea comprehensively; Simultaneously, described system also has simple in structure, be easy to realize, and low cost and other advantages, it can form an independently equipment, and is simply portable, also can be used as an additional function modules, is carried in the existing color ultrasound system to use, and the marketing prospect is better.
Description of drawings
Fig. 1 is the flow chart of the application's the viscoelastic method of ultrasound detection cornea.
Fig. 2 is the detection sketch map of the application's the viscoelastic system of ultrasound detection cornea.
The specific embodiment
The invention provides the viscoelastic method and system of a kind of ultrasound detection cornea, clearer, clear and definite for making purpose of the present invention, technical scheme and effect, below the present invention is described in more detail.Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
See also Fig. 1, it is the flow chart of the application's the viscoelastic method of ultrasound detection cornea.As shown in the figure, the viscoelastic method of described ultrasound detection cornea may further comprise the steps:
The sound wave focusing that S1, order have certain power is on cornea, and corneal produces an acoustic radiation force; Under the effect of described acoustic radiation force, cornea produces microvibration, and described vibration form with Lamb wave in cornea is outwards propagated;
S2, detect pulse to eyeball emission, described pulse forms echo in the eyeball tissue internal reflection, and receives described echo;
The information of S3, the vibration of extraction cornea from echo, and according to certain mathematical model, obtain elastic modelling quantity and the viscosity of cornea.
The below specifically describes for above-mentioned steps respectively:
Described step S1 is for making the sound wave focusing with certain power on cornea, and corneal produces an acoustic radiation force; Under the effect of described acoustic radiation force, cornea produces microvibration, and described vibration form with Lamb wave in cornea is outwards propagated.Because ultrasound wave is propagated in tissue, its intensity forms the Gradient distribution of sound field inevitably with the depth attenuation, and this gradient has formed the Unidirectional acting force-acoustic radiation force to tissue.Acoustic radiation force makes the tissue generation along the displacement of ultrasound emission axial (Z direction) during the motion beginning, this displacement produces two effects: the one, and axial compression stretching, thereby the mode with compressional wave is propagated forward, the 2nd because and the horizontal shear stress of adjacent tissue, produce the shearing wave of horizontal transmission, be presented as that horizontal each point is along the chronological shear displacemant of Z direction.Because cornea is a kind of tissue of laminate structure, when shearing wave was propagated within it, constantly the up-and-down boundary of cornea was had an effect, and produced the MODAL TRANSFORMATION OF A between refraction, reflection and shear wave and the compressional wave and formed Lamb wave.For the Viscoelastic Thin Plates (being cornea) that is immersed in the liquid, suppose the close and compressible wave-wave number in them of the density of thin plate and liquid much smaller than the Lamb wave wave number, then the asymmetric Lamb wave Dispersion Equation in the thin plate is as follows:
(1)
Wherein,
,
Angular frequency,
The Lamb wave phase velocity of frequency dependence,
The wave number of shearing wave,
Modulus of shearing,
The density (close with the density of water) of sample,
,
Equal half of thickness of sample.
Described step S2 detects pulse to the eyeball emission, and described pulse forms echo in the eyeball tissue internal reflection, and receives described echo.When cornea tissue has vibration, just comprised vibration information in the echo.
Described step S3 is the information of the vibration of cornea of extracting from echo, and according to certain mathematical model, obtains elastic modelling quantity and the viscosity of cornea.The echo-signal that receives
Be expressed as a 2D signal.The pulse of emission one-time detection, the echo at different depth place during then the echo-signal of different moment t represents to organize.Pulse recurrence frequency emission repeated detection pulse by certain obtains a pulse-echo sequence, and k represents the frame number of echo in this sequence.The amplitude of echo-signal and phase place are subject to the modulation of this some tissue vibration, and the phase place that can therefrom extract the tissue vibration by certain algorithm changes.When specific implementation, from amplification and the analog-to-digital processing through ultrasonic front-end circuit of radio frequency (RF) signal that receives, process through quadrature demodulation again, obtain the complex envelope of RF signal.To a certain monitoring point, the complex envelope signal of echo-signal consecutive frame carries out cross correlation process, can extract the signal of tissue vibration in this different depth.For two test points at a distance of certain distance, calculate the phase contrast of their vibration signals on certain degree of depth, can obtain the phase velocity of Vibration propagation
In the present embodiment, the mechanical behavior of Viscoelastic Thin Plates is described, modulus of shearing by introducing the Voigt model
Then be expressed as
, wherein
With
Respectively elastic modelling quantity and viscous modulus.Therefore, equation (1) can turn to about the Lamb wave phase velocity
, frequency
, elastic modelling quantity
And viscous modulus
Mathematical model, as follows:
This formula shows that Lamb wave speed is the function of elasticity, viscosity and Lamb wave frequency.Decompose the Lamb wave speed that obtains on each frequency by measuring Lamb wave and obtaining each frequency domain in the frequency domain decomposition
Can be estimated the elastic modelling quantity of sample by nonlinear fitting
And viscous modulus
, this is physical basis of the present invention.In the specific implementation, the viscoelastic estimation of corneal as mathematical model, is perhaps carried out certain approximate and simplification to equation (2) with equation (2), obtains the empirical equation (palpus is through the checking of experiment) that the cornea viscoelasticity is estimated, as the mathematical model of estimation.
Theoretical and experimental study shows that the speed of intracorneal Lamb wave is generally at 3 ~ 10m/s, and on medical supersonic, such spread speed can arrive with existing hardware detection fully.
Based on mathematical model
To elastic modelling quantity
And viscosity
Estimate it is typical nonlinear parameter estimation problem based on model, can adopt the non-linear least square algorithm for estimating to solve.Below the simple flow process of describing algorithm:
At first, suppose＜
,
One group of initial value;
Then, obtain the estimation of phase velocity spectrum based on " criterion of least squares "
, namely
Calculate again the phase velocity spectrum of estimating
With actual measurement phase velocity spectrum
Between error sum of squares, be expressed as
If
Do not reach default precision, upgrade
Value, return
Step; Otherwise calculate and stop gained
It is the estimated value of cornea viscoelastic parameters.
Can adopt the optimized algorithms such as iterative method or search method to obtain in the specific implementation
Optimal estimation, just no longer do too much here and given unnecessary details.
The present invention also provides a kind of ultrasound detection cornea viscoelastic system, and as shown in Figure 2, described system comprises: main control computer, radiating circuit, receiving circuit, excitation array element and detection array element; Described main control computer connects respectively radiating circuit and receiving circuit, and described radiating circuit connects excitation array element, and receiving circuit connects detection array element;
Wherein, described main control computer (for example PC) emissioning controling signal makes the array element emission ultrasonic pulse of being responsible for excitation in the ultrasonic probe focus on the cornea, makes the cornea vibration; The array element that order be responsible for to detect, emission detects pulse, and collects echo and send in the signal processing module by receiving circuit and process, and finally calculates the elastic modelling quantity and the viscosity that obtain cornea.Need to explanatorily be, ultrasonic probe can be designed, designed, also can adopt the linear array probe that is equipped with in the existing color ultrasound system.
Whole system can be utilized probe and the circuit of general medical ultrasonic system (or ultrasound biomicroscopy UBM), encourage and detect by software control, and from echo-signal, extract the spread speed of Lamb wave, estimate the viscoelasticity of cornea, an add-on module as existing ultrasonic system, also whole detection system can be comprised probe, hardware circuit and the software of being correlated with, be designed to an independently equipment.
Specifically, before the detection, oscillation starting points F and at least two test points with fine pitch (such as A point and B point) of definition tissue.The first step, the test point emission detects pulse, with the home position of record organization.Second step, the driving pulse of excitation array element transmitting focusing produces acoustic radiation force and acts on cornea, makes the tissue vibration of its oscillation starting points, and towards periphery horizontal transmission.This section driving pulse sustainable tens is to hundreds of μ s.Pulse can produce axial displacement by a relatively large margin for a long time, thereby the Lamb wave that can cause producing has larger signal to noise ratio.The 3rd step was to detect pulse to test point with certain pulse recurrence frequency emission, and the displacement on the detection certain depth is to the curve of time, and the principle of its principle and pulse Doppler is similar.
In sum, the viscoelastic method and system of ultrasound detection cornea of the present invention wherein, said method comprising the steps of: at first, the sound wave focusing that order has certain power is on cornea, and corneal produces an acoustic radiation force; Under the effect of described acoustic radiation force, cornea produces microvibration, and described vibration form with Lamb wave in cornea is outwards propagated; Then, detect pulse to the eyeball emission, described pulse forms echo in the eyeball tissue internal reflection, and receives described echo; At last, from echo, extract the information of the vibration of cornea, and according to certain mathematical model, obtain elastic modelling quantity and the viscosity of cornea.But its simultaneous quantitative is measured elastic modelling quantity and viscosity, portrays the mechanical characteristic of cornea comprehensively; Simultaneously, described system also has simple in structure, be easy to realize, and low cost and other advantages, and, can be used as an independently equipment, also can be used as an additional function modules, be carried in the existing color ultrasound system and use, the marketing prospect is better.
Should be understood that application of the present invention is not limited to above-mentioned giving an example, for those of ordinary skills, can be improved according to the above description or conversion that all these improvement and conversion all should belong to the protection domain of claims of the present invention.
Claims (4)
1. the viscoelastic method of ultrasound detection cornea is characterized in that, said method comprising the steps of:
The sound wave focusing that S1, order have certain power is on cornea, and corneal produces an acoustic radiation force; Under the effect of described acoustic radiation force, cornea produces microvibration, and described vibration form with Lamb wave in cornea is outwards propagated;
S2, detect pulse to eyeball emission, described pulse forms echo in the eyeball tissue internal reflection, and receives described echo;
The information of S3, the vibration of extraction cornea from echo, and according to certain mathematical model, obtain elastic modelling quantity and the viscosity of cornea.
2. the viscoelastic method of ultrasound detection cornea according to claim 1 is characterized in that, among the described step S3, the information of the vibration of cornea comprises: the waveform of vibration, and the phase velocity of Lamb wave is with the change information of frequency of vibration.
3. the viscoelastic method of ultrasound detection cornea according to claim 1 is characterized in that, also comprises before the described step S1: oscillation starting points F and at least two test points with fine pitch of definition cornea; The test point emission detects pulse, with the home position of record cornea.
4. the viscoelastic system of ultrasound detection cornea is characterized in that, comprising: main control computer, radiating circuit, receiving circuit, ultrasonic probe; Described main control computer connects radiating circuit and receiving circuit respectively by the transmitting/receiving gauge tap, each array element emission or reception ultrasonic pulse on the control ultrasonic probe;
Wherein, probe contains a plurality of array elements, and wherein a part of array element is used for the emission acoustic radiation force, the vibration of excitation tissue, and other has some array elements to be used for the emission ultrasonic pulse, and receives echo-signal, thereby detects the vibration information of tissue;
Wherein, described main control computer emissioning controling signal makes the array element emission ultrasonic pulse of being responsible for excitation in the ultrasonic probe focus on the cornea, makes the cornea vibration; The array element that order be responsible for to detect, emission detects pulse, and collects echo and send in the signal processing module by receiving circuit and process, and finally calculates the elastic modelling quantity and the viscosity that obtain cornea.
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| CN104367347A (en) * | 2014-05-16 | 2015-02-25 | 深圳大学 | System and method for measuring intra-ocular pressure and cornea viscoelasticity |
| CN105167805A (en) * | 2015-08-19 | 2015-12-23 | 深圳市亿领科技有限公司 | Cornea elasticity measurement method and cornea elasticity measurement device |
| CN105686852A (en) * | 2014-11-24 | 2016-06-22 | 深圳大学 | Ophthalmology diagnosis-based ultrasonic pulse excitation and echo acquisition system |
| CN106175831A (en) * | 2016-09-28 | 2016-12-07 | 重庆理工大学 | A kind of tissue viscoelasticity based on shearing wave amplitude and phase-detection measuring method |
| CN106840362A (en) * | 2017-03-20 | 2017-06-13 | 西安交通大学 | Vibration measurement with laser monitoring HIFU based on acoustic radiation force impulse response damages viscoelastic method |
| CN106963419A (en) * | 2015-12-04 | 2017-07-21 | 东芝医疗系统株式会社 | Resolver |
| CN106963424A (en) * | 2017-03-15 | 2017-07-21 | 深圳大学 | Detect the viscoelastic system and method for arteries |
| CN108982674A (en) * | 2017-06-05 | 2018-12-11 | 郑翊 | Wave property is sheared using single driving pulse and with different in width and multiple driving pulses of shape measurement tissue |
| CN109009229A (en) * | 2018-07-06 | 2018-12-18 | 深圳大学 | A kind of device and method of sclera mechanical characteristic in body quantitative measurment |
| WO2019015396A1 (en) * | 2017-07-21 | 2019-01-24 | 无锡海斯凯尔医学技术有限公司 | Method and device for measuring viscoelasticity of medium |
| CN109875504A (en) * | 2019-01-15 | 2019-06-14 | 温州医科大学 | One kind being based on the viscoelastic method of jet-propelled optical coherence elastography non-invasive measurement cornea |
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| CN110974148A (en) * | 2019-12-03 | 2020-04-10 | 温州医科大学 | Method for measuring cornea elastic modulus of in-vivo human eye based on jet optical coherence elastography technology |
| CN112022215A (en) * | 2020-09-03 | 2020-12-04 | 深圳大学 | Ultrasonic elastography cornea detection method, device and system and storage medium |
| CN113116381A (en) * | 2019-12-30 | 2021-07-16 | 重庆融海超声医学工程研究中心有限公司 | Method for detecting change in property of biological tissue, method for controlling denaturation, and corresponding device |
| WO2021212578A1 (en) * | 2020-04-24 | 2021-10-28 | 深圳迈瑞生物医疗电子股份有限公司 | Viscoelasticity measuring method, elasticity measuring method and ultrasonic measuring system |
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| CN104367347A (en) * | 2014-05-16 | 2015-02-25 | 深圳大学 | System and method for measuring intra-ocular pressure and cornea viscoelasticity |
| CN105686852A (en) * | 2014-11-24 | 2016-06-22 | 深圳大学 | Ophthalmology diagnosis-based ultrasonic pulse excitation and echo acquisition system |
| CN105167805A (en) * | 2015-08-19 | 2015-12-23 | 深圳市亿领科技有限公司 | Cornea elasticity measurement method and cornea elasticity measurement device |
| CN106963419A (en) * | 2015-12-04 | 2017-07-21 | 东芝医疗系统株式会社 | Resolver |
| CN106175831A (en) * | 2016-09-28 | 2016-12-07 | 重庆理工大学 | A kind of tissue viscoelasticity based on shearing wave amplitude and phase-detection measuring method |
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| WO2019015396A1 (en) * | 2017-07-21 | 2019-01-24 | 无锡海斯凯尔医学技术有限公司 | Method and device for measuring viscoelasticity of medium |
| CN109009229A (en) * | 2018-07-06 | 2018-12-18 | 深圳大学 | A kind of device and method of sclera mechanical characteristic in body quantitative measurment |
| CN109875504A (en) * | 2019-01-15 | 2019-06-14 | 温州医科大学 | One kind being based on the viscoelastic method of jet-propelled optical coherence elastography non-invasive measurement cornea |
| CN109875504B (en) * | 2019-01-15 | 2021-07-30 | 温州医科大学 | Method for non-invasively measuring corneal viscoelasticity based on jet optical coherence elastography technology |
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| CN110974148B (en) * | 2019-12-03 | 2022-01-07 | 温州医科大学 | Method for measuring cornea elastic modulus of in-vivo human eye based on jet optical coherence elastography technology |
| CN113116381A (en) * | 2019-12-30 | 2021-07-16 | 重庆融海超声医学工程研究中心有限公司 | Method for detecting change in property of biological tissue, method for controlling denaturation, and corresponding device |
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| CN112022215A (en) * | 2020-09-03 | 2020-12-04 | 深圳大学 | Ultrasonic elastography cornea detection method, device and system and storage medium |
| CN112022215B (en) * | 2020-09-03 | 2023-07-14 | 深圳大学 | Ultrasonic elastography cornea detection method, device, system and storage medium |
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Application publication date: 20130403 |